{"id":3065,"date":"2022-04-14T15:27:33","date_gmt":"2022-04-14T15:27:33","guid":{"rendered":"https:\/\/websumisura.com\/federicoselvaggi\/?p=3065"},"modified":"2026-04-24T15:34:28","modified_gmt":"2026-04-24T15:34:28","slug":"perineural-invasion-in-pancreatic-ductal-adenocarcinoma-from-molecules-towards-drugs-of-clinical-relevance","status":"publish","type":"post","link":"https:\/\/federicoselvaggi.com\/index.php\/2022\/04\/14\/perineural-invasion-in-pancreatic-ductal-adenocarcinoma-from-molecules-towards-drugs-of-clinical-relevance\/","title":{"rendered":"Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-bottom:48px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong>Introduction<\/strong><br \/>\nPancreatic ductal adenocarcinoma (PDAC) is a dismal disease characterized by poor prognosis, recurrence and resistance to chemotherapy [1,2]. PDAC is the second most frequent cancer of the gastrointestinal tract, the third principal cause of cancer overall<br \/>\nand the fourth major fatal illness in the United States. Curative surgery, defined as R0resection and adjuvant chemotherapy, is still currently the canonical regimen for patients with resectable, non-metastatic PDAC [3]. In advanced stages, when in the presence of local<br \/>\nor metastatic spread, a combination of gemcitabine and Nab-paclitaxel or mFOLFIRINOX is the usual treatment [4]. &#8230; (<a href=\"https:\/\/federicoselvaggi.com\/wp-content\/uploads\/2026\/04\/cancers-14-05793-v2.pdf\" target=\"_blank\" rel=\"noopener\">continua a leggere<\/a>)<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-padding-top:48px;--awb-bg-size:cover;--awb-width-large:100%;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div style=\"text-align:center;\"><a class=\"fusion-button button-flat fusion-button-default-size button-default fusion-button-default button-1 fusion-button-default-span fusion-button-default-type\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/federicoselvaggi.com\/wp-content\/uploads\/2026\/04\/cancers-14-05793-v2.pdf\"><span class=\"fusion-button-text awb-button__text awb-button__text--default\">Scarica il pdf<\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Villa Serena \u201cLe applicazioni del robot in chirurgia\u201d sfide attuali e prospettive future<\/p>\n","protected":false},"author":1,"featured_media":3067,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-3065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni-scientifiche"],"acf":[],"_links":{"self":[{"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/posts\/3065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/comments?post=3065"}],"version-history":[{"count":1,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/posts\/3065\/revisions"}],"predecessor-version":[{"id":3068,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/posts\/3065\/revisions\/3068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/media\/3067"}],"wp:attachment":[{"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/media?parent=3065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/categories?post=3065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/federicoselvaggi.com\/index.php\/wp-json\/wp\/v2\/tags?post=3065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}